![]() Another form of solid dispersions is pharmaceutical co-crystals, for which research has focused on understanding the chemistry, crystal engineering and physico-chemical properties. For the drug and the polymer to form a stable mixture they have to be miscible on a molecular basis. Some studies have shown that it is possible to maintain the drug in the amorphous form for extended periods of time. Specific interactions between the drug and the polymer may retard this spontaneous conversion of the amorphous drug. However, the amorphous form tends to recrystallize on storage, which limits the benefits of this approach. It also covers using glassy polymers to maintain the drug as amorphous exhibiting higher energy and entropy. This review looks at the progress made starting with crystalline carriers in the form of eutectics moving towards more complex crystalline mixtures. Crystalline and amorphous dispersions have been the focus of academic and industrial research due to their potential role in formulating poorly water-soluble drugs.
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